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KMID : 0620920210530101471
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Experimental & Molecular Medicine
2021 Volume.53 No. 10 p.1471 ~ p.1482
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Organoids as host models for infection biology ? a review of methods
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Aguilar Carmen
da Silva Marta Alves
Saraiva Margarida
Neyazi Mastura
Olsson I. Anna S.
Bartfeld Sina
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Abstract
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Infectious diseases are a major threat worldwide. With the alarming rise of antimicrobial resistance and emergence of new potential pathogens, a better understanding of the infection process is urgently needed. Over the last century, the development of in vitro and in vivo models has led to remarkable contributions to the current knowledge in the field of infection biology. However, applying recent advances in organoid culture technology to research infectious diseases is now taking the field to a higher level of complexity. Here, we describe the current methods available for the study of infectious diseases using organoid cultures.
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KEYWORD
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Adult stem cells, Biological models
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